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Women with PCOS should get their vitamin D levels checked ASAP

(What is vitamin D?) Vitamin D or cholecalciferol is the active form of vitamin D (D3) in the body. The conversion of UVB rays from the sun with a form of cholesterol in the skin, form a precursor to active D3 in the body. Cholecalciferol (active vitamin D), is formed after some changes are made to the precursor vitamin D in both the liver and kidneys.

Vitamin D has many functions in the body; commonly known for its immune-supporting properties and ability to balance calcium in the blood (contributing to bone health), vitamin D levels have also been linked to women’s health and PCOS outcomes.

 

How does vitamin D levels in the body affect PCOS outcomes?

The short story is, the hormonal imbalances in PCOS contribute to the development of a lot of inflammation and oxidative stress in the body. Vitamin D helps to decrease this inflammation with its anti-oxidant effects.

A study demonstrated that, when compared to controls, women with PCOS had lower serum vitamin D. Lower levels of vitamin D are associated with higher HOMA-IR (a marker that denotes insulin resistance in the body), and less favourable lipid levels in the blood. Women with both PCOS and who were deficient in vitamin D are more likely to have glucose dysregulation, increased levels of fasting blood sugar, thus, poor insulin resistance outcomes.

Another study found that supplementing vitamin D in women with PCOS, improved their hs-CRP (a marker for inflammation) and TAC (total antioxidant capacity).

Supplementing with vitamin D can improve insulin sensitivity, antioxidant capacity, and decrease inflammation, in women with hormonal imbalance and polycystic ovarian syndrome.

Women with PCOS should get their vitamin D tested ASAP!

Now especially, as we head into the winter months, there is a lot less sun exposure (in the northern hemisphere) with the days becoming shorter. Individuals with high pigmentation in their skin produce less vitamin D and are prone to have decreased serum levels especially in the winter months. Women with PCOS, particularly those who live in climates with less sun exposure, should have their levels tested as soon as possible in the upcoming season. Knowing their patient’s serum levels helps the clinician adequately dose vitamin D such that a woman with PCOS may benefit from improved blood sugar control, less inflammation, and improved immune health.

Special considerations: A note on the dangers of overdosing:

Yes, it is totally possible to overdose on vitamin D. It is a fat-soluble hormone: it is stored in the body’s fat cells. (Unlike B-vitamins which are water-soluble and produce the most vibrant pee, one ever did see). Vitamin D toxicity (hypervitaminosis): the presence of vitamin D in serum is to increase the levels of calcium in the blood. Increased levels of vitamin D can lead to higher amounts of blood calcium which may cause symptoms of nausea, vomiting, urination, and weakness. It may also lead to kidney problems. This is usually rare but can be caused by significantly increased supplementation.

For the women who come see me in my practice, I run tests to assess their serum vitamin D levels prior to supplementing with higher doses (often when doing vitamin D injections). Knowing your levels is crucial in creating a treatment plan to replenish your stores, reduce your symptoms of PCOS, and improve your body’s insulin response.

 

Are vitamin D injections may be right for you? Book a virtual discovery session with me today!

 

 


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You’ve just been (or about to be) diagnosed with PCOS for your irregular periods, now what?

Why is lab work important in understanding the progression and underlying causes of PCOS and its symptoms?

Treating symptoms alone is a band-aid solution to correcting a problem. Treating symptoms without the necessary investigation is like blindly applying a band-aid to a boo-boo and hoping you get it in the right spot. Why would you do that?

Likewise, why blindly put a band-aid on your health? I see a lot of women in my practice who either have a PCOS diagnosis or symptoms of PCOS, with very basic or little to no investigative lab work. These ladies have irregular cycles, intense carb cravings, a mighty hard time to lose weight, hair loss, and acne, and a whole lot of feeling pretty low about their appearance, health, and self-esteem.

Though these signs can be a flaming red sign pointing to PCOS, there are other root causes worth exploring. Why? PCOS is more than just irregular periods; insulin, thyroid hormones, and inflammation all contribute to the pattern of symptoms present.

As a naturopathic doctor, I encourage the awesome ladies I treat in my practice to consider a COMPLETE hormone investigation. This takes out the guesswork in piecing together which hormones are triggering your PCOS symptoms (i.e.: is it adrenal or insulin triggered?) while also giving us a baseline to build their specific treatment plans on.

Here is a snippet of the hormone-related labs I like to run in my patients.

  1. HbA1C: Marker for measuring how your blood sugar has been in the past 3 months. HbA1C value between 6.0%-6.4% indicates pre-diabetes. How well your body is at processing blood sugar reveals the risk of developing/already having insulin resistance; a key player in the worsening of PCOS symptoms, weight gain, and inflammation.
  2. SHGB: Sex Hormone Binding Globulin (try saying that 10 times fast!) Produced in the liver, SHBG has a high binding affinity for DHT (the hormone that causes male-type symptoms) and Testosterone. SHBG is like a sponge soaking up all that excess testosterone, keeping it from floating around in the blood.
  3. Androstenedione: Produced by the ovaries and adrenal glands, this steroid hormone marker is overproduced by the ovaries in PCOS.
  4. DHT: Dihydrotestosterone is produced by the conversion of testosterone by 5-a-reductase (an enzyme). DHT binds much strongly to testosterone receptors, and high levels have been attributed to male pattern balding in men and women.
  5. Ferritin: The storage form of iron. Some symptoms of low iron include fatigue, low mood, feeling cold, weakness, and hair loss*.
  6. TSH: Thyroid Stimulating Hormone acts on the thyroid gland to tell it to produce thyroid hormones (T3 and T4). We Measure TSH, T3 and T4 to rule out thyroid issues that may be contributing to irregular periods, hair loss, weight gain (i.e. hypothyroidism can present with hair loss, weight gain, irregular menstrual cycles, coldness, fatigue).

Notice how many PCOS symptoms are also present in other conditions or are affected by several hormones? Testing estrogen, LH, and FSH aren’t enough to help us understand the full hormonal picture. Yes, the symptoms look a heck of a lot like PCOS and you may even have a polycystic ovarian syndrome diagnosis, but until we understand the root cause and other hormonal and organ involvements, management and treatments are just a shot in the dark or conventional birth control pills.

 

Think you have PCOS and want to know how your specific hormonal pattern is affecting your periods? Connect with me here and let’s talk about finally improving your hormones so you can finally have a happy period!


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Hair loss.

Pain points

  1. Losing hair. Shedding a lot
  2. Can see bald spots
  3. No one is taking hair loss seriously
  4. Bad hair days. Low self-esteem

Causes:

  1. PCOS: androgenic alopecia. 
  2. Autoimmune: alopecia areata
  3. Hypothyroid
  4. Nutrient-related
  5. Tension alopecia traction alopecia  
  6. Telogen effluvium 
  7. Side effects of medications like the pill 

Conventional therapies

  1. Rogaine/minoxidil 
  2. Transplant
  3. PRP
  4. Drugs
  5. Birth Control

Other therapies (that are currently being explored)

  1. Acupuncture 
  2. Essential oils like rosemary (find research if it helps)
  3. Topical melatonin
  4. Correcting nutritional deficiencies!
  5. Herbs that correct the imbalance of hormones
  6. Scalp massage: to improve blood flow and decrease inflammation

Hair loss is a distressing symptom of a deeper imbalance in the body and is one of the symptoms that present in women with PCOS.

Hormonal dysregulation in PCOS presents with an increased amount of testosterone and androgens in the blood Which clinically manifests as acne, hirsutism (the growth of darker, more coarse hair on the chin, neck, and maybe cheeks), and alopecia.

Androgenic alopecia or female pattern hair loss (FPHL) is often experienced by women who have PCOS, but also by women who have a genetic sensitivity to testosterone and DHT (the more potent product of testosterone metabolism).

Understanding Hair loss Causes

  1. Female pattern: alopecia in women is seen as the loss of occipital hair and thinning on the vertex/crown area of the head. Often the thicker terminal hairs fall out and are replaced by thinner, lighter, and sparser vellus hairs. Unlike men who suffer from androgenic alopecia, women retain their frontal hairline. A current understanding of the mechanism of action for this pattern of hair loss, especially in men, is that the circulating testosterone gets converted to DHT by an enzyme called 5-a-reductase; DHT then acts on the hair follicles to minimize them. Research now suggests this is only part of the problem, as there is inflammation in the scalp about the follicles that also contributes to miniaturization.
  1. Alopecia Areata: present in both sexes, this type of hair loss presents as patchy spots of loss over the scalp. It is often worsened or triggered by stress, and some of my patients have also reported a tingling feeling in the scalp right before they notice the hair fall. This is an autoimmune type of hair loss.
  2. Hypothyroid hair loss: diffuse hair loss or hair that is dry, brittle, and breaks easily is a common symptom in those who also have an underactive thyroid.
  3. Nutrient deficiencies: Iron-deficiency (more common in menstruating women), presents with diffuse hair loss and low energy. Low levels of zinc, vitamin B1, biotin have also been linked to hair fall, while vitamin A toxicity can also contribute to alopecia.
  4. Tension or Traction alopecia: Tight ponytails, buns or updos pull on the root of the hair and subsequently lead to hair fall. This type of hair loss is usually noticed in the frontal hairline (where ever the hair is pulled the tightest).
  5. Telogen Effluvium: A non-inflammatory (and non-scarring) form of hair loss that occurs after an event (usually due to medications). This alopecia alters the growth cycle of hair, where the hair remains in the resting phase for longer periods of time. Hair shedding is noticed after medications like chemotherapy and generally begins to grow back after 2 months.
  6. Side effects of medications: Specifically, the birth control pills. Some BCPs are made with progestins (synthetic, almost-progesterone, which binds to progesterone receptors), that are more androgenic. Progestins such as Methyltestosterone, Gestodene, Levonorgestrel, -Norgestrel, and Desogestrel, contribute to the worsening of androgenic activity like hair loss, hirsutism, and acne.

Conventional Therapies

Medications are used to treat the underlying root cause of hair loss. In patients suffering from hypothyroidism, treatments involve medications such as levothyroxine to replace thyroid hormones not produced by the gland. Hair transplants are available for moderate to severe hair loss patients.

Topical conventional treatments include Rogaine (minoxidil), that can be purchased at the pharmacy and applied to the scalp twice a day. A reported side effect is increased hair growth on the face.

Women with androgenic alopecia (with or without PCOS), are often prescribed a mix of birth control pills (with the least androgenic activity) along with spironolactone. Drugs that block the activity of 5-a-reductase are used to decrease the conversion of testosterone to its more potent form, DHT. Commitment to conventional medications is often life-long, once stopped, the hair fall returns.

Other therapies like PRP, protein-rich plasma, are cosmetic procedures that aim to stop hair shedding by decreasing inflammation in the scalp and stimulating new hair growth.

Alternative Therapies

  1. Acupuncture: Done locally in the scalp, acupuncture causes a micro-trauma which stimulates blood flow to the area. Increased blood flow brings nutrients for the follicles, and may stimulate new hair growth while also decreasing local inflammation.
  2. Topical essential oils: Rosemary essential oil also may support new hair growth by improving circulation to the scalp.
  3. Topical Melatonin: Research suggests that a 0.1% melatonin solution applied nightly to the scalp improves hair growth in the occipital area of the scalp. It is suggested that melatonin may also act as an anti-inflammatory in the area. The same research finds that applying melatonin to the scalp did not affect blood concentration levels.
  4. Correcting nutritional deficiencies: while low levels of biotin are typically seen in rare genetic conditions, it is also present in patients taking medications for epilepsy, in those who consume large amounts of alcohol (also causes vitamin B1 deficiency), and smokers. Iron deficiency is common amongst menstruating women; while the range for “normal” ferritin levels is great, as a naturopathic doctor I like to see serum ferritin greater than 70 ng/mL.
  5. Herbs that may improve hair growth include those that support the elimination of excess testosterone and DHT from the body and others that block the conversion of testosterone to DHT. These include reishi, saw palmetto, nettle, licorice. Other herbs that support the production of estrogen and progesterone, like vitex and white peony may also help correct the hormonal imbalance in some women.
  6. Scalp massage stimulates blood flow to the hair follicles. Massage may also decrease inflammation. While more research needs to be conducted into the exact techniques, when and how often, massaging one’s scalp can relax the mind and decrease stress – win!

 

Female pattern hair loss (FPHL)/androgenic alopecia is a distressing symptom of hormonal imbalance and PCOS. FPHL may even trigger psychological symptoms of low mood and depression. In fact, hair shedding is often overlooked by many professionals as a reaction to stress or a short-term change in diet and lifestyle habits. Some women may not even notice that hair loss has occurred until at least 25% has fallen/not grown back. In my practice I focus on uncovering the root cause of hair fall, be it thyroid-related, hormonal, or even autoimmune; no one-size-fits-all approach is going to stimulate every patient’s hair growth. This process may take longer for some, but treating the appropriate root cause is worth it.

 

Note from Dr. Usman, ND

Please share this article! I personally know just how hard it is to find the right (and relevant) information out there. A lot of androgenic alopecia studies are conducted in men, and there isn’t enough evidence to support female hormonal balance and hair growth – yet. The more we talk about hair loss and natural therapies in women, the more we can support those experiencing female pattern hair loss.


If you’d like to book in with me to discuss hair shedding solutions, please click here.

 

 


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